​原著論文・総説（欧文）

2024

Jayathilake Sarangi, Ayaka Ido, Masaya Ito, Chihiro Iinuma, Yo Doyama, Wanchun Jin, Jun-Ichi Wachino, Masahiro Suzuki, Mitsutaka Iguchi, Tetsuya Yagi, Yoshichika Arakawa, Kouji Kimura             

Clinical isolates of Streptococcus mitis/oralis-related species with reduced carbapenem susceptibility, harboring amino acid substitutions in penicillin-binding proteins in Japan               

Antimicrobial agents and chemotherapy. 68(4): e0117923, 2024

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Jun-Ichi Wachino, Wanchun Jin, Chihiro Norizuki, Kouji Kimura, Motonori Tsuji, Hiromasa Kurosaki, Yoshichika Arakawa

Hydroxyhexylitaconic acids as potent IMP-type metallo-β-lactamase inhibitors for controlling carbapenem resistance in Enterobacterales

Microbiology Spectrum. 12(3):e0234423, 2024

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Natsumi Nakashima, Wanchun Jin, Jun-Ichi Wachino, Shinobu Koyama, Kiyoko Tamai, Yoshichika Arakawa , Kouji Kimura

β-Lactam Susceptibility of Streptococcus dysgalactiae subsp. equisimilis

Japanese journal of infectious diseases. 77(4):236-239, 2024

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2023

Rikuko Goto, Wanchun Jin, Jun-ichi Wachino, Yoshichika Arakawa, Kouji Kimura

Improved disk diffusion method for simple detection of group B streptococci with reduced penicillin susceptibility (PRGBS)

Diagnostic microbiology and infectious disease. 105(3):115881, 2023

 

Yoshihiro Yamaguchi, Koichi Kato, Yoshimi Ichimaru, Yuya Uenosono, Sakiko Tawara, Rio Ito, Natsuki Matsuse, Jun-ichi Wachino, Sachiko Toma-Fukai, Wanchun Jin, Yoshichika Arakawa, Masami Otsuka, Mikako Fujita, Nobuyuki Fukuishi, Kirara Sugiura, Masanori Imai, Hiromasa Kurosaki

Difference in the inhibitory effect of thiol compounds and demetallation rates from the Zn(II) active site of metallo-β-lactamases (IMP-1 and IMP-6) associated with a single amino acid substitution

ACS infectious diseases.9(1):65-78, 2023

 

Yusuke Tsuda, Masahiro Suzuki, Jun-ichi Wachino, Kouji Kimura K, Yoshichika Arakawa 

Bird's-eye MApping of plasmids (BeMAp) for visualization and comparison of genomic structures of different plasmids by mapping antimicrobial resistance genes on spreadsheets

Journal of microbiological methods.204:106645, 2023

 

2022

Masahiro Suzuki, Chihiro Norizuki, Jun-ichi Wachino, Kumiko Kawamura, Noriyuki Nagano, Yukiko Nagano, Wataru Hayashi, Kouji Kimura, Yohei Doi, Yoshichika Arakawa Dissecting the clonality of I1 plasmids using ORF-based binarized structure network analysis of plasmids (OSNAp)

Journal of infection and chemotherapy. 28(4):473-479, 2022

 

Jayathilake Sarangi, Nao Matsuo, Rina Nonogaki, Michiko Hayashi, Kumiko Kawamura, Masahiro Suzuki, Wanchun Jin, Kiyoko Tamai, Miho Ogawa, Jun-ichi Wachino, Kouji Kimura, Tetsuya Yagi, Yoshichika Arakawa

Molecular epidemiology of Enterobacter cloacae complex isolates with reduced carbapenem susceptibility recovered by blood culture

Japanese journal of infectious diseases. 75(1):41-48, 2022

 

2021

Tsubasa Ikeda, Rihito Suzuki, Wanchun Jin, Jun-ichi Wachino, Yoshichika Arakawa, Kouji Kimura             Isolation of group A Streptococci with reduced in vitro β-lactam susceptibility harboring amino acid substitutions in penicillin-binding proteins in Japan               

Antimicrobial agents and chemotherapy. 65(12): e0148221, 2021

 

Yoshihiro Yamaguchi, Koichi Kato, Yoshimi Ichimaru, Wanchun Jin, Misa Sakai, Miki Abe, Jun-ichi Wachino, Yoshichika Arakawa, Yukina Miyagi, Masanori Imai, Nobuyuki Fukuishi, Yuriko Yamagata, Masami Otsuka, Mikako Fujita, Hiromasa Kurosaki

Crystal structures of metallo-β-lactamase (IMP-1) and its D120E mutant in complexes with citrate and the inhibitory effect of the benzyl group in citrate monobenzyl ester

Journal of medicinal chemistry. 64(14):10019-10026, 2021

 

Chihiro Norizuki, Jun-ichi Wachino, Wanchun Jin, Kouji Kimura, Kumiko Kawamura, Noriyuki Nagano, Yoshichika Arakawa

Practical agar-based disk-diffusion tests using sulfamoyl heteroarylcarboxylic acids for identification of subclass B1 metallo-β-lactamase-producing Enterobacterales

Journal of clinical microbiology. 59(10)：e0076121, 2021

 

Takumi Ushino, Wanchun Jin, Jun-ichi Wachino, Yoshichika Arakawa, Kouji Kimura

Daptomycin susceptibility of group B Streptococcus

Japanese journal of infectious diseases. 74(3):233-235, 2021

 

2020

Jun-ichi Wachino, Yohei Doi, Yoshichika Arakawa

Aminoglycoside resistance, Review

Infectious disease clinics of North America. 34(4)：887-902, 2020

 

Jun-ichi Wachino, Wanchun Jin, Kouji Kimura, Hiromasa Kurosaki, Ayato Sato, Yoshichika Arakaw

Sulfamoyl heteroarylcarboxylic acids as promising metallo-β-lactamase inhibitors for controlling bacterial carbapenem resistance

mBio. 11(2):e03144-19, 2020

 

Nao Matsuo, Rina Nonogaki, Michiko Hayashi, Jun-ichi Wachino, Masahiro Suzuki, Yoshichika Arakawa, Kumiko Kawamura

Characterization of blaCTX-M-27/F1:A2:B20 plasmids harbored by Escherichia coli ST131 sublineage C1/H30R isolates spreading among elderly Japanese in non-acute care settings

Antimicrobial agents and chemotherapy. 64(5):e00202-20, 2020

 

2019

Jun-ichi Wachino, Reo Kanechi, Erina Nishino, Marie Mochizuki, Wanchun Jin, Kouji Kimura, Hiromasa Kurosaki, Yoshichika Arakawa

4-amino-2-sulfanylbenzoic acid as a potent subclass B3 metallo-β-lactamase-specific inhibitor applicable for distinguishing metallo-β-lactamase subclasses

Antimicrobial agents and chemotherapy. 63(10):e01197-19, 2019

 

Hiroaki Moroi, Kouji Kimura, Ayaka Ido, Hirotsugu Banno, Wanchun Jin, Jun-ichi Wachino, Keiko Yamada, Fumitaka Kikkawa, Yeon-Joon Park, Yoshichika Arakawa

Erythromycin-Susceptible but Clindamycin-Resistant Phenotype of Clinical ermB-PCR-Positive group B Streptococci isolates with IS1216E-inserted ermB

Japanese journal of infectious diseases. 72(6):420-422, 2019

 

Jun-ichi Wachino, Wanchun Jin, Kouji Kimura, Yoshichika Arakawa

Intercellular transfer of chromosomal antimicrobial resistance genes between Acinetobacter baumannii strains mediated by prophages

Antimicrobial agents and chemotherapy. 63(8):e00334-19, 2019

 

Kumiko Kawamura, Kazuki Kitaoka, Kouji Kimura, Jun-ichi Wachino, Takaaki Kondo, Yoshitsugu Iinuma, Nobuo Murakami, Shuhei Fujimoto, Yoshichika Arakawa

Spread of seb-Positive Methicillin-resistant Staphylococcus aureus SCCmec type II-ST764 among elderly Japanese in nonacute care settings

Microbial drug resistance. 25(6):915-924, 2019

 

Hiroaki Moroi, Kouji Kimura, Tomomi Kotani, Hiroyuki Tsuda, Hirotsugu Banno, Wanchun Jin, Jun-ichi Wachino, Keiko Yamada, Takashi Mitsui, Mamoru Yamashita, Fumitaka Kikkawa, Yoshichika Arakawa

Isolation of group B Streptococcus with reduced β-lactam susceptibility from pregnant women

Emerging microbes & infections. 8(1):2-7, 2019

 

Masaki Kitamura, Kouji Kimura, Ayaka Ido, Tomomi Seki, Hirotsugu Banno, Wanchun Jin, Jun-ichi Wachino, Keiko Yamada, Yoshichika Arakawa

Relatively high rates of cefotaxime- and ceftriaxone-non-susceptible isolates among group B streptococci with reduced penicillin susceptibility (PRGBS) in Japan

Journal of antimicrobial chemotherapy. 74(4):931-934, 2019

 

2018

Wataru Hayashi, Yusuke Ohsaki, Yui Taniguchi, Shota Koide, Kumiko Kawamura, Masahiro Suzuki, Kouji Kimura, Jun-ichi Wachino, Yukiko Nagano, Yoshichika Arakawa, Noriyuki Nagano

High prevalence of blaCTX-M-14 among genetically diverse Escherichia coli recovered from retail raw chicken meat portions in Japan

International journal of food microbiology. 284:98-104, 2018

 

Kumiko Kawamura, Kengo Hayashi, Nao Matsuo, Kazuki Kitaoka, Kouji Kimura, Jun-ichi Wachino, Takaaki Kondo, Yoshitsugu Iinuma, Nobuo Murakami, Shuhei Fujimoto, Yoshichika Arakawa

Prevalence of CTX-M-Type extended-spectrum β-lactamase-producing Escherichia coli B2-O25-ST131 H30R among residents in nonacute care facilities in Japan

Microbial drug resistance. 24(10):1513-1520, 2018

 

Kazuki Kitaoka, Kouji Kimura, Hiromitsu Kitanaka, Hirotsugu Banno, Wanchun Jin, Jun-ichi Wachino, Yoshichika Arakawa

Carbapenem-nonsusceptible Haemophilus influenzae with penicillin-binding protein 3 containing an amino acid insertion

Antimicrobial agents and chemotherapy. 62(8):e00671-18, 2018

 

Hirotsugu Banno, Kouji Kimura, Tomomi Seki, Wanchun Jin, Jun-ichi Wachino, Keiko Yamada, Noriyuki Nagano, Yoshichika Arakawa

High isolation rate and multidrug resistance tendency of penicillin-susceptible group B Streptococcus with reduced ceftibuten susceptibility in Japan

European journal of clinical microbiology & infectious diseases. 37(8):1511-1519, 2018

 

Chihiro Norizuki, Kumiko Kawamura, Jun-ichi Wachino, Masahiro Suzuki, Noriyuki Nagano, Takaaki Kondo, Yoshichika Arakawa

Detection of Escherichia coli producing CTX-M-1-group extended-spectrum beta-lactamases from pigs in Aichi prefecture, Japan, between 2015 and 2016

Japanese journal of infectious diseases. 71(1):33-38, 2018

 

Mitsuru Oodate, Kouji Kimura, Hirotsugu Banno, Satoru Yokoyama, Wanchun Jin, Jun-ichi Wachino, Yoshinori Hasegawa, Yoshichika Arakawa

Predominance of Serogroup 19 CC320/271 among penicillin-nonsusceptible Streptococcus pneumoniae Isolates after Introduction of the PCV7 Vaccine in Several Regions of Japan

Japanese journal of infectious diseases. 71(1):14-20, 2018

 

2017

Kumiko Kawamura, Noriyuki Nagano, Masahiro Suzuki, Jun-ichi Wachino, Kouji Kimura, Yoshichika Arakawa

ESBL-producing Escherichia coli and its rapid rise among healthy people

Food safety (Tokyo, Japan). 5(4):122-150, 2017

 

Kentaro Kato, Hiroshi Mizumoto, Kousaku Matsubara, Atsuko Hata, Jun-ichi Wachino, Yoshichika Arakawa, Daisuke Hata

Recurrence of Escherichia coli meningitis in a preterm infant and co-infection of echovirus 18

IDCases. 10:135-137, 2017

 

Hirotsugu Banno, Kouji Kimura, Yosuke Tanaka, Tsuyoshi Sekizuka, Makoto Kuroda, Wanchun Jin, Jun-ichi Wachino, Keiko Yamada, Keigo Shibayama, Yoshichika Arakawa

Analysis of multidrug resistant group B streptococci with reduced penicillin susceptibility forming small, less hemolytic colonies.

PLoS one. 12(8):e0183453, 2017

 

Wanchun Jin, Jun-ichi Wachino, Yoshihiro Yamaguchi, Kouji Kimura, Anupriya Kumar, Mototsugu Yamada, Akihiro Morinaka, Yoshiaki Sakamaki, Minoru Yonezawa, Hiromasa Kurosaki, Yoshichika Arakawa

Structural insights into the TLA-3 extended-spectrum β-lactamase and its inhibition by avibactam and OP0595

Antimicrobial agents and chemotherapy, 61(10):e00501-17, 2017

 

Chihiro Norizuki, Jun-ichi Wachino, Masahiro Suzuki, Kumiko Kawamura, Noriyuki Nagano, Kouji Kimura, Yoshichika Arakawa

Specific blaCTX-M-8/IncI1 plasmid transfer among genetically diverse Escherichia coli isolates between humans and chickens

Antimicrobial agents and chemotherapy. 61(6):e00663-17, 2017

 

Rina Taniguchi, Kouji Kimura, Akira Miyazaki, Hirotsugu Banno, Wanchun Jin, Keiko Yamada, Jun-ichi Wachino, Yoshichika Arakawa

High rate of slowly-killed-by-ampicillin phenotype among group B streptococci with reduced penicillin susceptibility

Journal of antimicrobial chemotherapy. 72(3):941-942, 2017

 

2016

Masato Inaba, Naoyuki Matsuda, Hirotsugu Banno, Wanchun Jin, Jun-ichi Wachino, Keiko Yamada, Kouji Kimura, Yoshichika Arakawa

In vitro reduction of antibacterial activity of tigecycline against multidrug-resistant Acinetobacter baumannii with host stress hormone norepinephrine

International journal of antimicrobial agents. 48(6):680-689, 2016

 

Yohei Doi, Jun-ichi Wachino, Yoshichika Arakawa

Aminoglycoside resistance: The emergence of acquired 16S ribosomal RNA methyltransferases

Infectious disease clinics of North America. 30(2):523-537, 2016

 

Shinako Fukigai, Makiko Morimoto, Kouji Kimura, Yo Doyama, Akira Miyazaki, Chitose Kamiya, Hirotsugu Banno, Eriko Morishima, Tomohiro Onoda, Noriyuki Nagano, Wanchun Jin, Jun-ichi Wachino, Keiko Yamada, Yoshichika Arakawa

Effectual detection of group B streptococci with reduced penicillin susceptibility (PRGBS) by commercially available methicillin-resistant-Staphylococcus aureus (MRSA)-selective agar

Diagnostic microbiology and infectious disease. 85(3):309-312, 2016

 

Jun-ichi Wachino, Yoshihiro Yamaguchi, Shigetarou Mori, Wanchun Jin, Kouji Kimura, Hiromasa Kurosaki, Yoshichika Arakawa

Structural insights into recognition of hydrolyzed carbapenems and inhibitors by subclass B3 metallo-β-lactamase SMB-1

Antimicrobial agents and chemotherapy. 60(7):4274-4282, 2016

 

Hiore Ohno, Jun-ichi Wachino, Ryoichi Saito, Wanchun Jin, Keiko Yamada, Kouji Kimura, Yoshichika Arakawa

A highly macrolide-resistant Campylobacter jejuni strain with rare A2074T mutations in 23S rRNA genes

Antimicrobial agents and chemotherapy. 60(4):2580-2581, 2016

 

2015

Ai Fujita, Kouji Kimura, Satoru Yokoyama, Wanchun Jin, Jun-ichi Wachino, Keiko Yamada, Hiroyuki Suematsu, Yuka Yamagishi, Hiroshige Mikamo, Yoshichika Arakawa

Characterization of piperacillin/tazobactam-resistant Klebsiella oxytoca recovered from a nosocomial outbreak

PLoS One. 10(11):e0142366, 2015

 

Tomomi Seki, Kouji Kimura, Megan E. Reid, Akira Miyazaki, Hirotsugu Banno, Wanchun Jin, Jun-ichi Wachino, Keiko Yamada, Yoshichika Arakawa

High isolation rate of MDR group B streptococci with reduced penicillin susceptibility in Japan

Journal of antimicrobial chemotherapy. 70(10):2725-2728, 2015

 

Tatsuki Mura, Kumiko Kawamura, Jun-ichi Wachino, Keigo Shibayama, Yoshichika Arakawa

Development of a novel chromogenic method, Penta-well test, for rapid prediction of β-lactamase classes produced in clinical Enterobacteriaceae isolates

Diagnostic microbiology and infectious disease. 83(1):25-29, 2015

 

Chitose Kamiya, Kouji Kimura, Yo Doyama, Akira Miyazaki, Makiko Morimoto, Hirotsugu Banno, Noriyuki Nagano, Wanchun Jin, Jun-ichi Wachino, Keiko Yamada, Yoshichika Arakawa

Ceftibuten-containing agar plate for detecting group B streptococci with reduced penicillin susceptibility (PRGBS)

Diagnostic microbiology and infectious disease. 82(4):269-273, 2015

 

Yoshihiro Yamaguchi, Satoshi Matsueda, Kazuyo Matsunaga, Nobutoshi Takashio, Sachiko Toma-Fukai, Yuriko Yamagata, Naohiro Shibata, Jun-ichi Wachino, Keigo Shibayama, Yoshichika Arakawa, Hiromasa Kurosaki

Crystal structure of IMP-2 metallo-β-lactamase from Acinetobacter spp.: comparison of active-site loop structures between IMP-1 and IMP-2

Biological & pharmaceutical bulletin. 38(1):96-101, 2015

 

Ryoko Yamada, Kouji Kimura, Noriyuki Nagano, Yukiko Nagano, Satowa Suzuki, Wanchun Jin, Jun-ichi Wachino, Keiko Yamada, Keigo Shibayama, Yoshichika Arakawa

Comparative Analysis of Penicillin-Susceptible and Non-Susceptible Isolates of Group B Streptococci by Multilocus Sequence Typing

Japanese journal of infectious diseases. 68(4):326-329, 2015

 

Wanchun Jin, Jun-ichi Wachino, Kouji Kimura, Keiko Yamada, Yoshichika Arakawa

New plasmid-mediated aminoglycoside 6 '-N-acetyltransferase, AAC(6 ')-Ian, and ESBL, TLA-3, from a Serratia marcescens clinical isolate

Journal of antimicrobial chemotherapy. 70(5):1331-1337, 2015

 

Ryota Ito, Yuichiro Shindo, Daisuke Kobayashi, Masahiko Ando, Wanchun Jin, Jun-ichi Wachino, Keiko Yamada, Kouji Kimura, Tetsuya Yagi, Yoshinori Hasegawa, Yoshichika Arakawa

Molecular epidemiological characteristics of Klebsiella pneumoniae associated with bacteremia among patients with pneumonia

Journal of clinical microbiology. 53(3):879-886, 2015

 

Takeshi Suzuki, Kouji Kimura, Hiroshi Suzuki, Hirotsugu Banno, Wanchun Jin, Jun-ichi Wachino, Keiko Yamada, Yoshichika Arakawa

Have group A streptococci with reduced penicillin susceptibility emerged?

Journal of antimicrobial chemotherapy. 70(4):1258-1259, 2015

 

Yukiko Nagasaka, Kouji Kimura, Keiko Yamada, Jun-ichi Wachino, Wanchun Jin, Shigeyuki Notake, Hideji Yanagisawa, Yoshichika Arakawa

Genetic profiles of fluoroquinolone-nonsusceptible Klebsiella pneumoniae among cephalosporin-resistant K. pneumoniae

Microbial drug resistance. 21(2):224-233, 2015

 

2014

Hiromitsu Kitanaka, Masa-aki Sasano, Satoru Yokoyama, Masahiro Suzuki, Wanchun Jin, Masami Inayoshi, Mitsuhiro Hori, Jun-ichi Wachino, Kouji Kimura, Keiko Yamada, Yoshichika Arakawa

Invasive infection caused by carbapenem-resistant Acinetobacter soli, Japan

Emerging infectious diseases. 20(9):1574-1576, 2014

 

Jun-ichi Wachino, Kouji Kimura, Keiko Yamada, Wanchun Jin, Yoshichika Arakawa

Evaluation of disk potentiation test using kirby-bauer disks containing high-dosage fosfomycin and glucose-6-phosphate to detect production of glutathione S-transferase responsible for fosfomycin resistance

Journal of clinical microbiology. 52(10):3827-3828, 2014

 

Genki Nakamura, Jun-ichi Wachino, Natsumi Sato, Kouji Kimura, Keiko Yamada, Wanchun Jin, Keigo Shibayama, Tetsuya Yagi, Kumiko Kawamura, Yoshichika Arakawa

Practical agar-based disk potentiation test for detection of fosfomycin-nonsusceptible Escherichia coli clinical isolates producing glutathione S-transferases

Journal of clinical microbiology. 52(9):3175-3179, 2014

 

Hiromitsu Kitanaka, Jun-ichi Wachino, Wanchun Jin, Satoru Yokoyama, Masaaki Sasano, Mitsuhiro Hori, Keiko Yamada, Kouji Kimura, Yoshichika Arakawa

Novel integron-mediated fosfomycin resistance gene fosK

Antimicrobial agents and chemotherapy. 58(8):4978-4979, 2014

 

Hirotsugu Banno, Kouji Kimura, Yosuke Tanaka, Hiromitsu Kitanaka, Wanchun Jin, Jun-ichi Wachino, Keiko Yamada, Keigo Shibayama, Yoshichika Arakawa

Characterization of multidrug-resistant group B Streptococci with reduced penicillin susceptibility forming small non-beta-hemolytic colonies on sheep blood agar plates

Journal of clinical microbiology. 52(6):2169-2171, 2014

 

Jun-ichi Wachino, Mari Matsui, Hoang Huy Tran, Masato Suzuki, Satowa Suzuki, Keigo Shibayama

Evaluation of a double-disk synergy test with a common metallo-β-lactamase inhibitor, mercaptoacetate, for detecting NDM-1-producing Enterobacteriaceae and Acinetobacter baumannii

Japanese journal of infectious diseases. 67(1):66-68, 2014

 

2013

Kouji Kimura, Hideji Yanagisawa, Jun-ichi Wachino, Keigo Shibayama, Yoshichika Arakawa

Rapid and reliable loop-mediated isothermal amplification method for detecting Streptococcus agalactiae

Japanese journal of infectious diseases. 66(6):546-548, 2013

 

Natsumi Sato, Kumiko Kawamura, Kunihiko Nakane, Jun-ichi Wachino, Yoshichika Arakawa

First detection of fosfomycin resistance gene fosA3 in CTX-M-producing Escherichia coli isolates from healthy individuals in Japan

Microbial drug resistance. 19(6):477-482, 2013

 

Kimura Kimura, Yasunobu Nishiyama, Seiichi Shimizu, Jun-ichi Wachino, Mari Matsui, Satowa Suzuki, Kunikazu Yamane, Keigo Shibayama, Yoshichika Arakawa

Screening for group B streptococci with reduced penicillin susceptibility in clinical isolates obtained between 1977 and 2005

Japanese journal of infectious diseases. 66(3):222-225, 2013

 

Kouji Kimura, Jun-ichi Wachino, Hiroshi Kurokawa, Mari Matsui, Satowa Suzuki, Kunikazu Yamane, Noriyuki Nagano, Keigo Shibayama, Yoshichika Arakawa

High cephalosporin resistance due to amino acid substitutions in PBP1A and PBP2X in a clinical isolate of group B Streptococcus

Journal of antimicrobial chemotherapy. 68(7):1533-1536, 2013

 

Kouji Kimura, Noriyuki Nagano, Yukiko Nagano, Jun-ichi Wachino, Keigo Shibayama, Yoshichika Arakawa

Ability of the VITEK(R) 2 system to detect group B streptococci with reduced penicillin susceptibility (PRGBS)

Journal of antimicrobial chemotherapy. 68(6):1442-1444, 2013

 

Kouji Kimura, Noriyuki Nagano, Yukiko Nagano, Satowa Suzuki, Jun-ichi Wachino, Keigo Shibayama, Yoshichika Arakawa

High frequency of fluoroquinolone- and macrolide-resistant streptococci among clinically isolated group B streptococci with reduced penicillin susceptibility

Journal of antimicrobial chemotherapy. 68(3):539-542, 2013

 

Jun-ichi Wachino, Yoshihiro Yamaguchi, Shigetarou Mori, Hiromasa Kurosaki, Yoshichika Arakawa, Keigo Shibayama

Structural Insights into the Subclass B3 Metallo-β-Lactamase, SMB-1, and the Mode of Inhibition by the Common Metallo-β-Lactamase Inhibitor, Mercaptoacetate

Antimicrobial agents and chemotherapy. 57(1):101-109, 2013

 

Kunikazu Yamane, Jun-ichi Wachino, Satowa Suzuki, Yoshichika Arakawa

Latency of Klebsiella species and Escherichia coli strains that harbor a conjugative IncA/C type plasmid carrying both rmtB and blaCTX-M-14

川崎医学会誌. 39(3):87-94, 2013

 

2012

Jun-ichi Wachino, Yoshichika Arakawa

Exogenously acquired 16S rRNA methyltransferases found in aminoglycoside-resistant pathogenic Gram-negative bacteria: An update

Drug resistance update. 15:133-148, 2012

 

Emiko Rimbara, Shigetarou Mori, Mari Matsui, Satowa Suzuki, Jun-ichi Wachino, Yoshiaki Kawamura, Zeli Shen, James G Fox, Keigo Shibayama

Molecular epidemiologic analysis and antimicrobial resistance of Helicobacter cinaedi isolated from 7 hospitals in Japan

Journal of clinical microbiology. 50(8):2553-2560, 2012

 

Jun-ichi Wachino, Yoshihiro Yamaguchi, Shigetarou Mori, Yuriko Yamagata, Yoshichika Arakawa, Keigo Shibayama

Crystallization and preliminary X-ray analysis of the subclass B3 metallo-β-lactamase SMB-1 that confers carbapenem resistance

Acta crystallographica. Section F, Structural biology and crystallization communications. 68(3):343-346, 2012

 

2011

Jun-ichi Wachino, Hiroyuki Yoshida, Kunikazu Yamane, Satowa Suzuki, Mari Matsui, Takuya Yamagishi, Atsuko Tsutsui, Toshifumi Konda, Keigo Shibayama, Yoshichika Arakawa

SMB-1, a novel subclass B3 metallo-beta-lactamase, associated with ISCR1 and a class 1 integron, from a carbapenem-resistant Serratia marcescens clinical isolate

Antimicrobial agents and chemotherapy. 55(11):5143-5149, 2011

 

Kouji Kimura, Noriyuki Nagano, Yukiko Nagano, Jun-ichi Wachino, Satowa Suzuki, Keigo Shibayama, Yoshichika Arakawa

Predominance of sequence type 1 group with serotype VI among group B streptococci with reduced penicillin susceptibility identified in Japan

Journal of antimicrobial chemotherapy. 66(11):2460-2464, 2011

 

Shigetarou Mori, Keigo Shibayama, Jun-ichi Wachino, Yoshichika Arakawa

Structural insights into the novel diadenosine 5′,5‴-P 1,P4-tetraphosphate phosphorylase from Mycobacterium tuberculosis H37Rv

Journal of molecular biology. 410(1):93-104, 2011

 

Jun-ichi Wachino, Kunikazu Yamane, Yoshichika Arakawa

Practical Disk-Based Method for Detection of Escherichia coli Clinical Isolates Producing the Fluoroquinolone-Modifying Enzyme AAC(6 ')-Ib-cr

Journal of clinical microbiology. 49(6):2378-2379, 2011

 

Keigo Shibayama, Hiroaki Takeuchi, Jun-ichi Wachino, Shigetarou Mori, Yoshichika Arakawa

Biochemical and pathophysiological characterization of Helicobacter pylori asparaginase

Microbiology and immunology. 55(6):408-417, 2011

 

2010

Jun-ichi Wachino, Keigo Shibayama, Kouji Kimura, Kunikazu Yamane, Satowa Suzuki, Yoshichika Arakawa

RmtC introduces G1405 methylation in 16S rRNA and confers high-level aminoglycoside resistance on Gram-positive microorganisms

FEMS microbiology letters. 311(1):56-60, 2010

 

Kumiko Kawamura-Sato, Jun-ichi Wachino, Takaaki Kondo, Hideo Ito, Yoshichika Arakawa

Correlation between reduced susceptibility to disinfectants and multidrug resistance among clinical isolates of Acinetobacter species

Journal of antimicrobial chemotherapy. 65(9):1975-1983, 2010

 

Jun-ichi Wachino, Keigo Shibayama, Satowa Suzuki, Kunikazu Yamane, Shigetarou Mori, Yoshichika Arakawa

Profile of expression of Helicobacter pylori gamma-glutamyltranspeptidase

Helicobacter. 15(3):184-192, 2010

 

Jun-ichi Wachino, Kunikazu Yamane, Satowa Suzuki, Kouji Kimura, Yoshichika Arakawa

Prevalence of fosfomycin resistance among CTX-M-Producing Escherichia coli clinical isolates in Japan and identification of novel plasmid-mediated fosfomycin-modifying enzymes

Antimicrobial agents and chemotherapy. 54(7):3061-3064, 2010

 

Yoshihiro Yamaguchi, Nobutoshi Takashio, Jun-ichi Wachino, Yuriko Yamagata, Yoshichika Arakawa, Koki Matsuda, Hiromasa Kurosaki

Structure of metallo-beta-lactamase IND-7 from a Chryseobacterium indologenes clinical isolate at 1.65-A resolution

Journal of biochemistry. 147(6):905-915, 2010

 

Shigetarou Mori, Keigo Shibayama, Jun-ichi Wachino, Yoshichika Arakawa

Crystallization and preliminary X-ray analysis of the diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase from Mycobacterium tuberculosis H37Rv

Acta crystallographica. Section F, Structural biology and crystallization communications. 66(3):279-281, 2010

 

2009

Kouji Kimura, Jun-ichi Wachino, Hiroshi Kurokawa, Satowa Suzuki, Kunikazu Yamane, Naohiro Shibata, Yoshichika Arakawa

Practical disk diffusion test for detecting group B Streptococcus with reduced penicillin susceptibility

Journal of clinical microbiology. 47(12):4154-4157, 2009

 

Shigetarou Mori, Keigo Shibayama, Jun-ichi Wachino, Yoshichika Arakawa

Purification and molecular characterization of a novel diadenosine 5’,5’’’-P(1),P(4)-tetraphosphate phosphorylase from Mycobacterium tuberculosis H37Rv

Protein expression and purification. 69(1):99-105, 2009

 

Yoshihiro Yamaguchi, Genta Sato, Yuriko Yamagata, Yohei Doi, Jun-ichi Wachino, Yoshichika Arakawa, Koki Matsuda, Hiromasa Kurosaki

Structure of AmpC beta-lactamase (AmpC(D)) from an Escherichia coli clinical isolate with a tripeptide deletion (Gly286-Ser287-Asp288) in the H10 helix

Acta crystallographica. Section F, Structural biology and crystallization communications. 65(6):540-543, 2009

 

Zhenyu Piao, Keigo Shibayama, Shigetarou Mori, Jun-ichi Wachino, Yoshichika Arakawa

A novel insertion sequence, IS1642, of Mycobacterium avium, which forms long direct repeats of variable length.

FEMS microbiology letters. 291(2):216-221, 2009

 

Satowa Suzuki, Naohiro Shibata, Kunikazu Yamane, Jun-ichi Wachino, Kenitiro Ito, Yoshichika Arakawa

Change in the prevalence of extended-spectrum-beta-lactamase-producing Escherichia coli in Japan by clonal spread

Journal of antimicrobial chemotherapy. 63(1):72-79, 2009

 

Yukiko Nagano, Noriyuki Nagano, Jun-ichi Wachino, Keiko Ishikawa, Yoshichika Arakawa

Novel chimeric beta-lactamase CTX-M-64, a hybrid of CTX-M-15-like and CTX-M-14 beta-lactamases, found in a Shigella sonnei strain resistant to various oxyimino-cephalosporins, including ceftazidime

Antimicrobial agents and chemotherapy. 53(1):69-74, 2009

 

2008

Kouji Kimura, Satowa Suzuki, Jun-ichi Wachino, Hiroshi Kurokawa, Kunikazu Yamane, Naohiro Shibata, Noriyuki Nagano, Haru Kato, Keigo Shibayama, Yoshichika Arakawa

First molecular characterization of group B streptococci with reduced penicillin susceptibility

Antimicrobial agents and chemotherapy. 52(8):2890-2897, 2008

 

Yohei Doi, Jun-ichi Wachino, Yoshichika Arakawa

Nomenclature of plasmid-mediated 16S rRNA methylases responsible for panaminoglycoside resistance

Antimicrobial agents and chemotherapy. 52(6):2287-2288, 2008

 

Kunikazu Yamane, Jun-ichi Wachino, Satoawa Suzuki, Yoshichika Arakawa

Plasmid-mediated qepA gene among Escherichia coli clinical isolates from Japan

Antimicrobial agents and chemotherapy. 52(4):1564-1566, 2008

 

Kumiko Kawamura-Sato, Jun-ichi Wachino, Takaaki Kondo, Hideo Ito, Yoshichika Arakawa

Reduction of disinfectant bactericidal activities in clinically isolated Acinetobacter species in the presence of organic material

Journal of antimicrobial chemotherapy. 61(3):568-576, 2008

 

2007

Yoshihiro Yamaguchi, Wanchun Jin, Kazuyo Matsunaga, Shinnji Ikemizu, Yuriko Yamagata, Jun-ichi Wachino, Naohiro Shibata, Yoshichika Arakawa, Hiromasa Kurosaki

Crystallographic investigation of the inhibition mode of a VIM-2 metallo-beta-lactamase from Pseudomonas aeruginosa by a mercaptocarboxylate inhibitor

Journal of medicinal chemistry. 50(26):6647-6653, 2007

 

Jun-ichi Wachino, Keigo Shibayama, Hiroshi Kurokawa, Kouji Kimura, Kunikazu Yamane, Satowa Suzuki, Naohiro Shibata, Yasuyoshi Ike, Yoshichika Arakawa

Novel plasmid-mediated 16S rRNA m(1)A1408 methyltransferase, NpmA, found in a clinically isolated Escherichia coli strain resistant to structurally diverse aminoglycosides

Antimicrobial agents and chemotherapy. 51(12):4401-4409, 2007

 

Kunikazu Yamane, Jun-ichi Wachino, Satowa Suzuki, Naohiro Shibata, Haru Kato, Keigo Shibayama, Kouji Kimura, Kumiko Kai, Satoshi Ishikawa, Yoshiyuki Ozawa, Toshifumi Konda, Yoshichika Arakawa

16S rRNA methylase-producing, gram-negative pathogens, Japan

Emerging infectious diseases. 13(4):642-646, 2007

 

Kunikazu Yamane, Jun-ichi Wachino, Satowa Suzuki, Kouji Kimura, Naohiro Shibata, Haru Kato, Keigo Shibayama, Toshifumi Konda, Yoshichika Arakawa

New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Eschefichia coli clinical isolate

Antimicrobial agents and chemotherapy. 51(9):3354-3360, 2007

 

Keigo Shibayama, Jun-ichi Wachino, Yoshichika Arakawa, Massoud Saidijam, Nicholas G. Rutherford, Peter J. F. Henderson

Metabolism of glutamine and glutathione via gamma-glutamyltranspeptidase and glutamate transport in Helicobacter pylori: possible significance in the pathophysiology of the organism

Molecular microbiology. 64(2):396-406, 2007

 

2006

Keigo Shibayama, Mitsuaki Nagasawa, Takafumi Ando, Masaaki Minami, Jun-ichi Wachino, Satowa Suzuki, Yoshichika Arakawa

Usefulness of adult bovine serum for Helicobacter pylori culture media

Journal of clinical microbiology. 44(11):4255-4257, 2006

 

Jun-ichi Wachino, Kunikazu Yamane, Kouji Kimura, Naohiro Shibata, Satowa Suzuki, Yasuyoshi Ike, Yoshichika Arakawa

Mode of transposition and expression of 16S rRNA methyltransferase gene rmtC accompanied by ISEcp1

Antimicrobial agents and chemotherapy. 50(9):3212-3215, 2006

 

Naohiro Shibata, Hiroshi Kurokawa, Yohei Doi, Tetsuya Yagi, Kunizkazu Yamane, Jun-ichi Wachino, Satowa Suzuki, Satoshi Ishikawa, Haru Kato, Keigo Shibayama, Kumiko Kai, Toshifumi Konda, Yoshichika Arakawa.

PCR classification of CTX-M-type beta-lactamase genes identified in clinically isolated gram-negative bacilli in Japan

Antimicrobial agents and chemotherapy. 50(2):791-795, 2006

 

Jun-ichi Wachino, Hiroshi Kurokawa, Satowa Suzuki, Kunikazu Yamane, Naohiro Shibata, Kouji Kimura, Yasuyoshi Ike, Yoshichika Arakawa

Horizontal transfer of bla(CMY)-bearing plasmids among clinical Escherichia coli and Klebsiella pneumoniae isolates and emergence of cefepime-hydrolyzing CMY-19

Antimicrobial agents and chemotherapy. 50(2):534-541, 2006

 

Jun-ichi Wachino, Kunikazu Yamane, Keigo Shibayama, Hiroshi Kurokawa, Naohiro Shibata, Satowa Suzuki, Yohei Doi, Kouji Kimura, Yasuyoshi Ike, Yoshichika Arakawa

Novel plasmid-mediated 16S rRNA methylase, RmtC, found in a proteus mirabilis isolate demonstrating extraordinary high-level resistance against various aminoglycosides

Antimicrobial agents and chemotherapy. 50(1):178-184, 2006

 

2005

Kunikazu Yamane, Jun-ichi Wachino, Yohei Doi, Hiroshi Kurokawa, Yoshichika Arakawa

Global spread of multiple aminoglycoside resistance genes

Emerging infectious diseases. 11(6):951-953, 2005

 

Tetsuya Yagi, Jun-ichi Wachino, Hiroshi Kurokawa, Satowa Suzuki, Kunikazu Yamane, Yohei Doi, Naohiro Shibata, Haru Kato, Keigo Shibayama, Yoshichika Arakawa

Practical methods using boronic acid compounds for identification of class C beta-lactamase-producing Klebsiella pneumoniae and Escherichia coli

Journal of clinical microbiology. 43(6):2551-2558, 2005

 

2004

Kyoko Kanai, Keigo Shibayama, Satowa Suzuki, Jun-ichi Wachino, Yoshichika Arakawa

Growth competition of macrolide-resistant and susceptible Helicobacter pylori strains

Microbiology and immunology. 48(12):977-980, 2004

 

Jun-ichi Wachino, Yohei Doi, Kunikazu Yamane, Naohiro Shibata, Tetsuya Yagi, Takako Kubota, Yoshichika Arakawa

Molecular characterization of a cephamycin-hydrolyzing and in hibitor-resistant class A beta-lactamase, GES-4, possessing a single G170S substitution in the Omega-loop

Antimicrobial agents and chemotherapy. 48(8):2905-2910, 2004

 

Yohei Doi, Jun-ichi Wachino, Masaji Ishiguro, Hiroshi Kurokawa, Kunikazu Yamane, Naohiro Shibata, Keigo Shibayama, Keiko Yokoyama, Haru Kato, Tetsuya Yagi, Yoshichika Arakawa

Inhibitor-sensitive AmpC beta-lactamase variant produced by an Escherichia coli clinical isolate resistant to oxyiminocephalosporins and cephamycins

Antimicrobial agents and chemotherapy. 48(7):2652-2658, 2004

 

Yohei Doi, Jun-ichi Wachino, Kunizkazu Yamane, Naohiro Shibata, Tetsuya Yagi, Keigo Shibayama, Haru Kato, Yoshichika Arakawa

Spread of novel aminoglycoside resistance gene aac(6 ')-Iad among Acinetobacter clinical isolates in Japan

Antimicrobial agents and chemotherapy. 48(6):2075-2080, 2004

 

Jun-ichi Wachino, Yohei Doi, Kunikazu Yamane, Naohiro Shibata, Tetsuya Yagi, Takako Kubota, Hideo Ito, Yoshichika Arakawa

Nosocomial spread of ceftazidime-resistant Klebsiella pneumoniae strains producing a novel class A beta-lactamase, GES-3, in a neonatal intensive care unit in Japan

Antimicrobial agents and chemotherapy. 48(6):1960-1967, 2004

 

Yohei Doi, Keiko Yokoyama, Kunikazu Yamane, Jun-ichi Wachino, Naohiro Shibata, Tetsuya Yagi, Keigo Shibayama, Haru Kato, Yoshichika Arakawa

Plasmid-mediated 16S rRNA methylase in Serratia marcescens conferring high-level resistance to aminoglycosides

Antimicrobial agents and chemotherapy. 48(2):491-496, 2004

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